One of the most important aspects of hemp consumption is finding the right dose for your individual needs. The mantra "start low and go slow" isn't just cautionary advice – it's the foundation of a positive hemp experience backed by decades of clinical research and patient experience.
The Science of Hemp Dosing
Hemp dosing is highly individualized due to the complex interaction between cannabinoids, terpenes, and individual endocannabinoid system variations. Research shows that the wellness window for hemp can be narrow, with optimal effects occurring within specific dose ranges that vary significantly between individuals.
The biphasic nature of hemp means that low doses can produce different effects than high doses. For example, low-dose THC (2.5-5mg) may reduce anxiety, while higher doses (15mg+) might increase anxiety in some individuals.
Understanding Potency and Bioavailability
Flower Products: Typically range from 10-35% THC, with premium strains reaching up to 40%. Bioavailability through inhalation is approximately 30-50%.
Concentrates: Can contain 60-90% THC, requiring extremely careful dosing. Start with rice grain-sized amounts.
Edibles: Usually contain 2.5-100mg THC per serving. Bioavailability is lower (6-20%) but effects last 4-8 hours due to first-pass metabolism creating 11-hydroxy-THC.
Tinctures: Sublingual administration offers 12-35% bioavailability with onset in 15-45 minutes.
Comprehensive Dosing Factors
Biological Factors
Endocannabinoid System Variations: Genetic polymorphisms in CB1 and CB2 receptors affect individual sensitivity. Some people naturally produce more or fewer endocannabinoids.
Tolerance Development: Regular use leads to CB1 receptor downregulation, requiring higher doses. Tolerance breaks of 48-72 hours can help reset sensitivity.
Body Composition: THC is fat-soluble and stored in adipose tissue. Body fat percentage affects both onset and duration of effects.
Liver Metabolism: CYP2C9 and CYP3A4 enzyme variations affect how quickly THC is metabolized, particularly important for edibles.
Environmental Factors
Food Intake: Consuming cannabis with fatty foods increases absorption. Empty stomach consumption leads to faster onset but potentially more intense effects.
Hydration: Proper hydration affects absorption and can help mitigate side effects like dry mouth.
Sleep and Stress: These factors can significantly impact how cannabis affects you on any given day.
Method-Specific Dosing Guidelines
Inhalation (Flower, Vapes)
Beginners: 1-2 small puffs, wait 15 minutes between doses
Experienced: Adjust based on tolerance, but avoid overconsumption
Onset: 2-10 minutes
Duration: 1-3 hours
Edibles
Beginners: 1-2.5mg THC, wait minimum 2 hours
Low Tolerance: 2.5-5mg THC
Moderate Tolerance: 5-10mg THC
High Tolerance: 10-20mg THC
Onset: 30 minutes to 2 hours
Duration: 4-8 hours
Tinctures (Sublingual)
Beginners: 1-2.5mg THC held under tongue for 60-90 seconds
Onset: 15-45 minutes
Duration: 2-4 hours
CBD Dosing Considerations
CBD dosing follows different principles than THC. Research suggests effective CBD doses range from 5-300mg daily, depending on the condition being addressed. Unlike THC, CBD has a more linear dose-response relationship and doesn't typically cause intoxication.
For general wellness, 10-40mg daily is common. For specific concerns, some individuals may benefit from higher doses (100-300mg), but this should be approached gradually and ideally with healthcare provider guidance.
Microdosing Protocol
Microdosing involves consuming sub-perceptual amounts of hemp (0.5-2mg THC) to achieve benefits without impairment. This approach can be particularly effective for anxiety, creativity enhancement, and general wellness support.
Safety and Overconsumption
Hemp overconsumption, while not life-threatening, can be uncomfortable. Symptoms include anxiety, paranoia, rapid heartbeat, and nausea. If you consume too much:
- Stay calm and remind yourself it will pass
- Find a quiet, comfortable environment
- Stay hydrated
- Try CBD if available (it can counteract THC effects)
- Consider black pepper (contains caryophyllene, which may help)
Building Your Personal Dosing Strategy
Effective dosing is a personal journey that requires patience and systematic approach. Keep detailed records of dose, timing, effects, and duration. Note environmental factors like food intake, stress levels, and sleep quality. This data becomes invaluable for optimizing your hemp experience.
Medical Considerations
If you're using hemp for specific health conditions, work with a healthcare provider familiar with hemp medicine. Medical dosing often requires different approaches than recreational use, with emphasis on consistent, measured doses rather than variable consumption.